UK Blood Transfusion Services

Oxford Clinical Research in Transfusion Medicine

Systematic Review Initiative (SRI)

The remit of the Systematic Review Initiative (SRI) is to develop the evidence base for the practice of transfusion medicine by producing systematic reviews of both randomised and, increasingly, non-randomised trials in transfusion. Approximately half of the work of the SRI is undertaken in collaboration with The Cochrane Collaboration. Projects completed to date include systematic reviews of the use of fresh frozen plasma and recombinant factor VIIa, prophylactic platelets in haematological malignancy, stem cells for acute myocardial infarction and chronic heart disease, the management of trauma-induced haemorrhage, and a series of systematic reviews exploring the evidence for the bedside practice of transfusion medicine. The output of our work is used to inform clinical practice and the research agenda. A number of clinical trials have originated from the output of our reviews.

Another important area of our work is the creation and development of the Transfusion Evidence Library, a comprehensive online library of systematic reviews and randomised controlled trials relevant to transfusion medicine. The Transfusion Evidence Library has been compiled according to strict methodological criteria, is fully searchable and contains abstracts and full text links where available. The Transfusion Evidence Library currently contains 720 systematic reviews, over 4,000 randomised controlled trials (1997 to present) and 57 economic evaluations. It is updated monthly and is published and distributed by Evidentia Publishing.

For more information on the work of the Systematic Review Initiative, including details of our current projects, citations for all our systematic reviews and information on our core staff, please visit: 


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